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Posts Tagged ‘medical’

PTR-TOF in the spotlight at IABR Breath Summit 2016

IONICON’s PTR-TOFMS technology has become the leading method for real-time breath gas analysis.

The International Association for Breath Research (IABR) held its annual summit conference at the renowned ETH Zürich in Switzerland. Between September 14 – 16, 2016, the latest scientific results in breath research were presented. In 12 talks researchers featured PTR-MS as their tool of choice for real-time breath gas analysis.

IONICON life PTR-TOF demonstration at the Breath Summit 2016 in Zuerich.

IONICON life PTR-TOF demonstration at the IABR Breath Summit 2016 in Zurich.

The popularity of PTR-MS, and especially PTR-TOF, reflects the various advantages these instruments offer for breath gas research. The Time-of-Flight (TOF) system analyses the complete ionized spectrum in a fraction of a second with a resolution sufficient to resolve isobaric compounds. The high sensitivity allows the detection of ppt-concentrations from a single exhalation. (more…)

PTR-MS breath test shows potential for detecting liver disease

Researchers at the University of Birmingham have published results that suggest a non-invasive breath test for liver disease using an IONICON PTR-MS. Elevated levels of limonene in patients have been found to be indicative of a diseased liver.

Especially in the UK liver disease has risen sharply over the past few decades and is the third biggest cause of premature mortality. Patients do not often present with symptoms until the disease is advanced. Even then diagnosis is difficult and the symptoms are often general and can be mistaken for other pathologies.

Breath gas analysis is a non-invasive method to collect information on the state of an individual by monitoring the concentration of the volatile organic compounds (VOCs) present in the exhaled breath, which are directly correlate to their concentrations in blood.

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Breath Analysis with PTR-MS has been certified for clinical use

IONICON launches the BET-med, a PTR-MS inlet system for real-time breath analysis approved for clinical use.

BET-med system

Breath gas analysis is a fast growing field of research with many potential applications that are being or are still waiting to be explored. Most instruments analyze samples offline, where samples collected into bags or onto traps can suffer from partial degradation of breath metabolites or manifestation of artifacts. IONICON PTR-MS instruments offer the possibility to analyze breath directly and in real-time with many advantages: A whole breath cycle can be monitored and both the end-tidal breath and the room-air concentrations can be extracted. IONICON developed a special sampling inlet for breath analysis that is based on Buffered-End-Tidal (BET) Sampling, which extends the time for the analysis of the end-tidal breath fraction and allows for LODs in the low pptv range from a single exhalation (see Winkler et al. 2013).  This device has now been approved for clinical use.

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Ionimed’s medical research on coverpage

Cover Page Gyn-Activ

As a partner in the research framework ONCOTYROL (Center for personalized cancer medicine), Ionimed Analytik has conducted clinical breath gas analysis to investigate new ways for breast cancer screening. This work has now been picked by the Austrian journal GYN-AKTIV as their cover story for issue 6/2012 (in german). In this project Ionimed has employed an Ionicon PTR-TOF 8000 for the analysis of breath samples from more than 200 patients and controls.

Find the story in GYN-AKTIV 6/2012 (in German): pdf

Overview Article on Biotech and Medical Applications

After several years of intense research in close collaboration international partners from both, medical research and biopharmaceutical companies, Ionimed Analytik has released an overview articel, summarizing this work.

This technical article Applications of PTR-MS in Medicine and Biotechnology has been published in American Laboratory (Tuesday, June 14, 2011) and is available online via this link.

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